PCL102H1 Lecture Notes - Lecture 5: Cell Adhesion, Metastasis, Angiogenesis
27 Apr 2016
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Document Summary
Six hallmarks of cancer: sustaining proliferating signalling. Cell surface receptors is constantly on on position: evading growth suppressors, activating invasion and metastasis. Decreased cell to cell adhesion, secretion of proteases that digest surrounding barriers: enabling replicative immortality. Activate telomerase to restore and maintain telomeres at end of chromosomes retain ability to divide continuously: inducing angiogenesis. Formation of new blood vessels from pre-existing vessels. Provides o2 and nutrients for cancer cells: resisting cell death. Oncogenes accelerate cell growth and division normally, there are growth factors that bind to receptors on cells to stimulate cell growth in cancer, cells grow regardless of presence of external signals. Tumour suppressor genes slow down cell division and induce apoptosis in cancer, they are inactivated. There"s a long lag time between dna damage and cancer detection. One treatment for all cytotoxic (cell-killing) interfere with dna replication not cancer specific kills all rapidly dividing cells.
