PCL102H1 Lecture Notes - Lecture 1: New Drug Application, Pyrosequencing, Francis Collins
14 Sep 2016
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Pcl102h1 spring 2013 the art of drug discovery. Required textbook: collins, f. (2009) the language of life: dna and the revolution in personalized medicine (roughly from the u of t bookstore); other required readings are posted on portal. Cave paintings from ancient egypt, mesopotamia, greece. Serious illnesses led to the belief of supernatural forces sorcerers, shamans, medicine men. Greeks: rejected the idea of supernatural and believed in rational concepts drugs: galen: presented the knowledge of greek medicine. Dark ages: christian church believed that fate lies with the almighty alone: however, christianity did not extend to arab, which held similar beliefs as the. Renaissance: invention of printing press; physician paracelsus. Analogues are drug alternatives for where the original drug have unwanted side effects. Experiment: using craig clark"s assay, choose any cone snail, inject a mouse with the cone snail"s venom, and follow any activity in the mouse.
