Lecture 2 Drug Basics

29 views4 pages
11 Apr 2012
Lecture 2 PCL201 Drug Basics
What is the difference between a drug and a toxin?
adverse effects
naturally formed
may be used as a drug
can cause harm.
Toxicant man-made
can be naturally produced
can cause harm
may be a toxin
What is a drug?
Pills, cough syrup, injectables
Cigarettes (nicotine and other compounds) coffee (caffeine: given to babies to
activate neonatal breathing response, athletes), wine (sedatives)
Natural herbal compounds
Recreational drugs (cocaine)
A compound that changes, alters, or blocks a physiological/chemical process
A substances intended for use in the diagnosis, treatment, mitigation, cure, or
prevention of disease in human beings or animals and a substance, other than food,
intended to affect the structure or any function of the body of a human being or
Any substance that can be used to modify a chemical process or processes in the
body, for example to treat an illness, relieve a symptom, enhance a performance or
ability, or to alter states of mind.
Pharmacology deals with the “desired” effect and toxicology deals with the
“adverse” effects or “poisonous effects”.
It can replace (Agonist)/assist a natural chemical from the body. (Selective
Serotonin Reuptake Inhibitor – SSRI for depression)
oAlzheimer’s Disease (increase acetylcholine)
oParkinson’s Disease (increase Dopamine)
oBlocks the metabolism of neurotransmitters
oNormally neurotransmitter is released and received. Depression reduced
release. Prozac blocks reuptake of neurotransmitter, increasing the amount
of neurotransmitter in synaptic cleft, prolonging activity.
It can be a novel compound that acts on a site in the body to activate or inhibit
something (Non-steroidal Anti-Inflammatory Agent – NSAID)
oNSAID blocks enzymes that form prostaglandins in cycloxygenase
E.g. Aspirin, Ibuprofen (Advil)
It can change or block/inhibit formation of compound/chemical in body.
Unlock document

This preview shows page 1 of the document.
Unlock all 4 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.