Lecture 25 Adverse Drug Reactions

32 views2 pages
22 Apr 2012
School
Department
Course
Professor
Lecture 25 Adverse Drug Reactions – Teratogenesis
Drug use in pregnancy
Drug effects in pregnancy rarely evaluated befre market release
Use not recommended unless benefits justify risk
Teratogenic: factor with harmful effect n fetus
Types of malformations
Major: structural/functional defects, medical/surgical intervention necessary,
incompatible with life, impair individuals’ capability to function normally in
society.
Minor: unusual morphological traits, no serious medical/cosmetic consequences to
child.
Thalidomide
Antiemetic during pregnancy
Limb reduction defect, other abnormalities
Critical period of exposure 45-50 days after first day of last menstrual period
Critical Periods
Pregnancy 3 trimesters, ~3 months each
Also can be divided into: egg/embryo/fetus
Egg: preimplantation, zygote formation until blastocyst implants in uterine wall
miscarriage
Embryo: implantation – 8th week of development, rapid growth, differentiation,
organ system development major structural anomalies
Fetus abnormal organ differentiation, growth, function
Direct effects of drugs on fetus (cellular)
Receptor-mediated toxicity: relatively predictable/proportional to drug
concentration
Reactive intermediate mediated toxicity
oProteratogens biotransformed to electrophiles, free radicals target DNA,
proteins, lipids
Indirect effects of drug on fetus (maternal effects)
Poor nutrition
Disease states
Altered blood supply to fetus
Effects on fetus/infant
Malformation, disruption, deformation
Fetal loss
Fetal toxicity/withdrawal
Unlock document

This preview shows half of the first page of the document.
Unlock all 2 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.