PCL201H1 Lecture Notes - Lecture 25: Abacavir, Hemolytic Anemia, Contact Dermatitis

• School: UTSG
• Department: Pharmacology and Toxicology
• Course: PCL201H1
• Professor: all

Document Summary

Introduction to adverse drug reactions (adrs: types and classification of adrs, monitoring of adrs. There is (cid:374)o (cid:862)sil(cid:448)er (cid:271)ullet(cid:863): can occur any time during therapy, or even many years after (thalidomide) may or may not be predictable, adrs include drug-drug interactions. Vioxx (rofecoxib): cox2 inhibitor, an analgesic/anti-i(cid:374)fla(cid:373)(cid:373)atory for patie(cid:374)ts (cid:449)ho (cid:272)a(cid:374)"t take. Increased risk of heart attacks, so drug withdrawn from market: valdecoxib had severe skin reactions, so also withdrawn, hint: -coxib = cox inhibitor. There is a spectrum of adr severity, from mild to lethal. Where risk > benefit, it is often favored to continue the drug. Adrs are one of the leading causes of morbidity and mortality (4th-6th in us), very costly. Risk factors: genetics and history of adrs, age (not by itself, but associated with impaired renal and hepatic function, polypharmacy, and other factors, gender (females more susceptible, types and classification of adrs. Caused by genetics or allergy (4 types of immunologic responses, see below)