PCL201H1 Lecture Notes - Lecture 10: Plasma Protein Binding, Glycoprotein, Orosomucoid

• School: UTSG
• Department: Pharmacology and Toxicology
• Course: PCL201H1
• Professor: all

Document Summary

Lecture 10 drug distribution continued: examine factors that affect the vd. Disease states: examine the importance of blood flow and the (cid:272)on(cid:272)ept of (cid:862)redistri(cid:271)ution(cid:863, examine factors that affect the vd. Binding is reversible, equilibrium between bound and unbound drugs. Only free drugs can leave blood to exert effect or be eliminated. Increasing [drug] beyond saturation will increase [free drug] Total drug concentration refers to all drugs in the body, bound & unbound. There are two important plasma proteins for binding. Binds weak acids, hormones, and bilirubin lowered in disease states. Binds weak bases increased levels during inflammation. Bound drugs may not be eliminated as readily (exception: active transport elimination) Bound drugs serve as a circulating reservoir, decreased intensity but longer duration. Most important for drugs with low kd at low [ ] Can decrease [free drug] decreased effect. Saturation may occur to increase [free drug] Drug binding is affected by drug-endogenous compound interactions and drug-drug interactions.