PCL481H1 Lecture Notes - Lecture 10: Autophagy, Thioredoxin Reductase, Steric Effects
26 Feb 2017
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Document Summary
Lipid peroxidation of hydroxyl radical (linolenic acid residue) Centres in gray are reactive and unstable: membrane lips are destroyed, reactive groups damage other cellular molecules. Ethane is a non-reactive end-product: biomarker of lipid peroxidation. Radical atom can move to another location because it"s a conjugated system : moving a radical due to lack of steric hindrance , molecular o2 can be added and lipid peroxy radical can be formed. Lh (lipid) comes in and interacts with peroxy radical hydro-peroxide. Iron2 iron3 alkoyl radical (chemicaly unstable) breaks down to give rise to a 2 carbon bi-product . Break down of linolenic acid lipid dysfunction. In the process of this fragmentation we get ethane (a gas) and is not reactive. Other end products are reactive because more radicals are being formed: but now you"ve damaged the lipid and created more lipid radicals, an assay can be used to measure peroxidation. Measures ethane production where linoleic acid has 2 carbons chopped off.
