PHC320H1 Lecture Notes - Lecture 34: Wetting, Bulk Density, Excipient
Document Summary
Wettability is related to hydrophobicity and interaction with solid with solvent. Compressibility interested since we want to make tablet so important. So right particle size range + unicofmr composition =major considerations for preparations of powders. Menthol, thymol, salol can be used with camphor to make a qliuid so form eutectic mixtures. If we use paraffin type of base ointment, we used mineral oil which is a compatible with paraffin type base, so for same drug depending on which ointment we want to prepare we select different levigating agent. Solid properties including melting temperature, solubility and stability solubility related to dissolution and this influence toxicity and bioavability. Stability issue use crystalline form since usually stable compared to amorphous form and then stability can change. Other methods based on stoke"s law big container, people can use collection from different locations at different times to get different size of particles, and mechanism based on distance of sedimentation, same mechanism as stoke"s law.