PHC320H1 Lecture Notes - Lecture 35: Amorphous Solid, Ionic Compound, Zinc Chloride
24 Mar 2015
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Document Summary
Solid forms influence many different processes , and first is the manufacturing then dissolution. Bioavability which is related to efficacy and toxicity some drugs have narrow therapeutic window and index once drug level is too low, then no therapeutic effect, if dose is high then toxic. Tylenol tablet question this is related to drug"s crystalline form since we can"t make them into tablets. Carbon atoms form crystal structures too, like atom bonds hold carbon together to form diamond, these are covalent bonds. There are organic molecules held by h-bonds and van der walls forces, not as strong as covalent bonds, not as strong as ionic bonds. Crystalline solids usually have a sharp melting point, if we run thermal analyses we can see peak of melting. Amorphous if naturally conversion it will go to crystalline form solubility for crystalline solid is lower than amorphous solid, and if dissolution is limiting step then crystalline form will give lower bioaviability.
