Targeting the EGFR: Iressa

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Department
Pharmaceutical Chemistry
Course
PHC320H1
Professor
Giaever
Semester
Winter

Description
The EGF ReceptorRTK family of cell surface receptorsIncludes epidermal growth factor receptor EGFRErb1Her1 and its relatives Receptors of EGFR subgroup essential for embryonic development and adult tissue homeostasis in vertebrates and invertebratesAbnormal activation associated with a variety of cancersEGFR overexpression in several human tumorsPrognostic significance of EGFR overexpression in selected cancers Poor prognosis low survival high risk of metastasesEGFR pathwaysRasproliferationPI3KAkt cell cycle progression or survivalNonsmallcell lung cancer NSCLCLeading cause of cancerrelated mortalityCurrent therapiesoMinor gainesoCombine chemosurgeryradiotherapyo15 5 year sur
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