Wnt and Hedgehog Signalling Pathways

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Department
Pharmaceutical Chemistry
Course
PHC320H1
Professor
Giaever
Semester
Winter

Description
Wnt signaling in development and diseaseNormal Roles multiple Wnt pathways regulate cell proliferation cell fates stem cell renewal and cell behavior in both embryos and adultsDiseases cancers bone density neurodegenerative diseases retinal diseaseEnt development of dorsal axis stem cell renewalWnt Family19 members in man and miceCystine rich glycoproteinsLipid modifiedFrizzled receptors10 members7 transmembrane receptrsnot sure if they engage G proteinsactivate cytoplasmic protein Dishevelled but mechanism unclearWnt transductionBTrCPSCF Ubiquitin lifase regulates Wnt signalingMutations within Wnt signaling pathway members leads to constitutive activation of the pathway and cancersWnt prevents ubiquinitation of Bcateninbuildupp of BcateninWnt signaling in intestinal homeostasisEpithelial cellsconstant turnover Stem cells at base of cryptWnt pathway controls stem cell renewal differentiation Uncontrolled Wnt signaling ab
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