PCL102H1 Lecture Notes - Lecture 12: Personalized Medicine, Statistical Significance, Pharmacodynamics
6 Mar 2018
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In illumine, they are attached to slides that are covered with primers. In 454: the dna is amplified around the bead using dna polymerase and regular dna building blocks. In illumine, amplify close to original tree to generate forest. Certain cancer drugs work best/worst (understanding biology disease and cancer): Each dot represents a combination of a mutation in the individual. We don"t want to see the red ones, where the drug doesn"t work, and we want to see that the drug is sensitive to the mutation, we want to see the green dots. We are looking at the combination of the gene was just chance, or it it was very unlikely to happen by chance. Something that didn"t happen (cid:271)y (cid:272)han(cid:272)e has high statisti(cid:272)al signifi(cid:272)an(cid:272)e. we are most interested in the top of the graph because they have high statistical significance, they pro(cid:271)a(cid:271)ly didn"t happen (cid:271)y (cid:272)han(cid:272)e. Microarrays are to look for changes in gene expression.
