PCL201H1 Lecture 5: Lecture 5 Dose Response
Document Summary
Response varies with time, and can be varied with dose. It is possible to saturate a signaling cascade. Common profile associated with specific drug interaction: saturation, leveling off with increased dosage. Increased dose, increased response, with saturation at high doses, can lo longer elicit greater response. A fairly uncommon profile associated with non-specific drug interaction is a linear relationship between response and dose, indicating that increased response proportional to dose, no maximal dose. Dose response vs. logdose response: compression, straight mid-segment, parallelism for drugs with similar mechanisms, you can compare two drugs working on same system. Parallelism for drugs of similar mechanism of action. Semi-logarithmic transformation: expands concentration scale at low concentration (binding changes rapidly, compresses concentration scale at high concentration (binding changes slowly, does not change the value of kd (affinity) Emax the maximal response achieved by an agonist efficacy. Ec50: ed50 (effective dose, similar to ec50) drug concentration at 50% of emax potency; reflects affinity of d-r.
