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Worlsey (24)
Lecture 4

Lecture 4 Drug Receptor Interaction

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
Lecture 4 PCL201 DrugReceptor InteractionsDrug interactions occur with biological proteinsMost drugreceptor interactions areReversibleVia weak chemical bondsIrreversible drugreceptor interactions areRareVia strong chemical bonds aspirin or antitumor drugsUndesirableEg aspirinCox bind irreversiblyModel Enzyme Substrate InteractionThe Lock and Key ModelNatural CompoundAgonist binds to receptor to initiate signaling cascadeDrug mimics natural compound similar chemical interactions activates signaling cascadeDrugReceptor interaction similar to substrateenzyme reactionSpecificoEnantiomers mirror imagesDifferent enantiomers may interact differently can affect dosesCan be inhibited blocked through other moleculesRever
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