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Lecture 2

Lecture 2 Drug Basics

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University of Toronto St. George

Lecture 2 PCL201 Drug BasicsWhat is the difference between a drug and a toxinToxinadverse effects poisonousnaturally formedmay be used as a drug can cause harmToxicantmanmadeDrugcan be naturally producedcan cause harmmay be a toxinWhat is a drugPills cough syrup injectablesCigarettes nicotine and other compounds coffee caffeine given to babies to activate neonatal breathing response athletes wine sedativesNatural herbal compoundsRecreational drugs cocaineA compound that changes alters or blocks a physiologicalchemical processA substances intended for use in the diagnosis treatment mitigation cure or prevention of disease in human beings or animals and a substance other than food intended to affect the structure or any function of the body of a human being or animalAny substance that can be used to modify a chemical process or processes in the body for example to treat an illness relieve a symptom enhance a performance or ability or to alter states of mindPharmacology deals with the desired effect and toxicology deals with the adverse effects or poisonous effectsIt can replace Agonistassist a natural chemical from the body Selective Serotonin Reuptake InhibitorSSRI for depressionoAlzheimers Disease increase acetylcholineoParkinsons Disease increase DopamineoBlocks the metabolism of neurotransmittersoNormally neurotransmitter is released and received Depressionreduced release Prozac blocks reuptake of neurotransmitter increasing the amount of neurotransmitter in synaptic cleft prolonging activityIt can be a novel compound that acts on a site in the body to activate or inhibit something Nonsteroidal AntiInflammatory AgentNSAIDoNSAID blocks enzymes that form prostaglandins in cycloxygenase pathwayEg Aspirin Ibuprofen AdvilIt can change or blockinhibit formation of compoundchemical in body
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