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PCL201H1 (59)
Worlsey (24)
Lecture 17

Lecture 17 Biotransformation III

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
Flavincontaining monooxygenases FMOsNADPH dependent oxygenation on nucleophilic P N S atoms of xenobiotic moleculesSubstrates thioether and carbamate pesticides ephedrine phenothiazines Nmethylamphetamine trimethylamine6 members of FMO gene family FMO123456genetic defect in FMO3 causes trimethyaminuria fish odor syndromeoFMO3 is reuired for trimethylamine to be biotransformed into a nonodorous compoundMonoamine oxidase MAO a Phase 1 oxidation enzymeNorepinephrinealdehydeNH3 deaminationSubstrates neurotransmitters epinephrine dopamine serotonin2 isoforms MAOAB found in CNSMAO inhibitors treat depressionTerminate action of neurotransmittersReduction NADPH quinone reductaseDetoxification of doxorubicin anticancer drughydroquinoneoQuinone reductase prevents cytotoxitity by copeting with P450 reductase via 2
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