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Lecture 11

Lecture 11 Clinical Pharmacology

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Lecture 11 PCL201 Clinical PharmacologyBioavailability FFraction of uncharged drug reaching systemic circulationMeasure as AUCMeasures extent of absorption and first passFf1E fabsorptionIV 100 rapid onsetIM 75100 larger volume than SCSC 75100 smaller volume than IMstPO 5100 convenient 1 passstPR 30100 less 1 pass than POInhalation 5100 rapid onsetTransdermal 80100 slow onset prolonged durationOral dosingCapsule disintegrates dissolves and absorbed via GITst1 pass effectreduced bioavailabilityDr slow to increase while absorption takes placeplasmaDrdecreasesslightly as it equilibrates with all compartmentsplasmaDrdecreases with e
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