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Canada (508,934)
Pharmacology (260)
PCL201H1 (59)
Worlsey (24)
Lecture

Lecture 24 Perinatal Pharmacology

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
Lecture 24 Perinatal PharmacologyPhysiological changes in pregnancyLower albumin concentrationsHigher Plasma volume cardiac output renal blood flow renal elimination uterine blood flow changes in enzyme activityPharmacokinetic changesAbsorptionoNauseavomitingoHormonal changes delayed gastric emptying prolonged bowel transit timesoDelayed Cmax onset of actionoLater changes in gastric pH increase ionization diffusion across gut membraneoIncreased cardiab output pulmonary blood flowaffect absorption of topicalinhaled agentsDistributionoIncreased plasma volume VdoIncreased cardiac output uterine renal perfusion Increased Clearance Lower CssoIncrease
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