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Lecture

Lecture 30 The Pharmacology of Reward and Drug Misuse

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
Lecture 30 The Pharmacology of Reward and Drug MisuseImportance of RewardRegulates controls behavior by inducing pleasurable effectsRewardreinforces behavior increases intensityMesolimbic dopamine systemProblematic drug useMaladaptive pattern of useimpairmentdistressAssociated with nonmedicinal useOpposite of responsible drug useNot dependencyBoth licit illict legal illegalSpectrum of Psychoactive Substance UseABeneficialPositive health spiritual social impactBCasualNonproblematicRecreational casual with negligible healthsocial effectsCProblematicNegative consequencesDChronic DependenceHabitual despite negative healthsocial effectsHow Problematic Drug use happensDrug prescribed initially as therapeutic agentExposure in recreational settingsDrug addictionChronic relapsing disorder persistent drugseeking drug taking behaviorCycle of cravingrelapseRoute of administration physiological effects of drug play role in addictionAssociated with activation of reward pathway in braineuphoriaSubstance Abuse Theories HypothesesActivation of brain reward systemoMaladaptive learning Longterm potentiation longterm depressionPhysical dependenceGeneticBehavioralenvironmental cues associationsDopaminereward Addiction TheoryMesolimbic system scans for reward situationAddictive drug increases dopamine inappropriatelyreinforcement
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