Class Notes (834,152)
Canada (508,380)
Pharmacology (260)
PCL201H1 (59)
Worlsey (24)
Lecture

Lecture 31 Street Drugs

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Department
Pharmacology
Course
PCL201H1
Professor
Worlsey
Semester
Winter

Description
Lecture 31 Street DrugsMarijuana 9Tetrahydrocannavinol THCPharmacodynamicsoTHC binds to CB1 CB2 receptorCB1 in CNSActivation of presynaptic CB1 receptor inhibits Glutamate GABA releaseoMimics endogenous ligandsAnadamide 2arachidonylglycerol synthesized on cellular depolarization calcium influxRetrograde synaptic messengersCannabis Pharmacokinetics depends on route of administrationoBioavailability oral vs inhaledoLipid solubleoBiliary excretion of metabolitesExtended half lifeActive metabolite 11OHTHCEffectsoTHC powerful psychoactive compoundEuphoria relaxation drowsinessLarge doses grandeur change perception of time p
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