PCL481H1 Lecture Notes - Lecture 6: Western Blot, Oxidative Stress, Cytoskeleton

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Map2k, phosphorylate kinases, map-mitogen associated protein kinases. Toxin- large molecule like enzyme or protein. At low levels of lf, mapkk-3 is cleaved: At high levels of lf, macrophage lysis occurs within hours, by an unknown mechanism: macrophages are one of the most important components of invading pathogens, killing macrophages- a profound effect occurs very quickly. During early infection when lf is low: Inhibition or delay of immune response allows pathogen to survive and multiply to high levels : macrophage lysis occurs and causes a high level of cell debris . Present in the blood stream and causes the sudden release of pro-inflammatory mediators causes septic shock *: at high levels the immune system overcomes it after being slowed septic shock. This phosphorylation generates downstream signals, cell growth, apoptosis, and inflammation. Permanent loss of the barrier function of the plasma membrane (when the do cells out membrane is no longer able to doo barrier function it is dead)

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