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Class Notes for Pharmacology and Toxicology at University of Toronto St. George

PCL102H1 Lecture Notes - Lecture 4: Genome-Wide Association Study, Data Mining, Macromolecule
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Target Identification Validation ** We are still in the DiscoveryPreclinical Testing stage ** Drug Target molecule (usually a protein - 96) involved in a medical problem that is acted on by a drug to stop that disease - P...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture 5: High-Throughput Screening
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Chemistry High-Throughput Screening ** We are still in the DiscoveryPreclinical Testing stage ** Chemical Libraries (many chemical starting points, might become drugs) - Medicinal chemists make chemicals since we dont kno...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture 6: Structure-Based Drug Development & Improving Your Chemical Compound
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Structure-Based Drug Development Improving Your Chemical Compound Discovering protein structure x-ray crystallography (ie. growing a crystal of pure protein) 1. Start with very small amount of concentrated protein in solu...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 8: Lead Compound, Morning Sickness, Rodent
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Drug Safety Preclinical Models Central question before beginning clinical trials (ie. testing on humans) is it safe? - Do no harm guiding principle for physicians - Dose-dependency for toxicity - Historical concern unsafe...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 7: Edward Jenner, Polypharmacy, Quinine
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The History of Drug Discovery Many theories - Believe that healing the sick is a matter of god and disease is a punishment - Belief in magic and the supernatural - disease caused by demons must be expelled by their route o...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 3: Tumor Suppressor Gene, Cancer, Benign Tumor
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Understanding Disease Mechanisms ** This is still in the discoverypreclinical testings stage ** Cancer disease of uncontrolled growth; includes spreading (ie. malignant tumours) into normal tissues and to other parts of th...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 2: New Drug Application, Lead Compound, Drug Discovery
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Lecture 2:DrugDiscovery Pipeline Unmet Medical Needs Unmet medical need: a condition whose treatment or diagnosis is not addressed adequately by available therapy (e.g. Many neurological disorders) o Includes: an immediate...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture 6: Structure-based Drug Development
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Lecture6:Structure-basedDrugDevelopmentandImprovingyourChemicalCompounds Structure-based drug development X-ray crystallography: technique used for determining the atomic and molecular structure of a crystal XRC can be use...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 5: High-Throughput Screening, Chemical Library, Phenotypic Screening
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Lecture5:ChemistryandHigh-ThroughputScreening High-throughput Screening High throughput screening occurs in the discoverypreclinical testing phase of the drug discovery pipeline Chemical library = many chemical starting po...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 3: Tumor Suppressor Gene, Metastasis, Breast Cancer
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Lecture2: UnderstandingDiseaseMechanisms:Cancer Cell Biology Changes in Cancer In Canada 1 or 3 individuals will get cancer and 1 in 4 will die from cancer Cancer is disease of uncontrolled tissue growth which also include...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture 8: Drug Safety and Preclinical Models
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Lecture8:DrugSafetyandPreclinicalModels Historical Issues in Drug Safety Common knowledge that toxicity is related to dose (i.e. Everything is toxic at a high enough dose even water) We are concerned about drug safety beca...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture 4: Identification and Validation
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Lecture4:TargetIdentificationandValidation What are Targets Target identification and target validation fits in the drug discovery pipeline Drug target: a molecule, usually a protein involved in a medical problem that is a...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 2: Drug Discovery, Prescription Drug, Generic Drug
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1152019 Drug Discovery Pipeline 2019 - Google Docs Drug Discovery Pipeline 2019 CONTEXT more than 1000 prescription drugs marketed in North America; 48 of US population is taking AT LEAST one prescription drug; huge market...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 19: Neglected Tropical Diseases, Zika Virus, Miskito People
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PCL102 MARCH 10 Classical drug: Its a long and very expensive process. This process takes 1215 years and it costs 12 billion . Neglected tropical diseases where: They are present throughout the world. Nigeria is considered...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa
PCL102H1 Lecture Notes - Lecture 23: Toxicology Testing, Health Canada, Antigen
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PCL102 March 24: Specialty drugs: Biolgics are produced by cells. Discovery process: Sometimes biologics can result with immune reaction because they are such large molecules, the bodys immune system can react to it. To pr...

Pharmacology and Toxicology
PCL102H1
Rebecca Laposa

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