PSL300H1 Lecture Notes - Secretion, Voltage, Nernst Equation
Document Summary
2 shapes, one is open, other is closed. Voltage gated channels: some membrane channels are sensitive to the potential difference across the membrane, conformation changes causing a pore to be created, the voltage sensing mechanism is in the 4th trans membrane domain of the protein, the. No more electrical attraction so s4 wing migrates up: when up, stuff can go through. Ligand gated channels: cell membrane receptors are part of the body"s chemical signalling system, ligand binding with receptor triggers stuff at membrane e. g. activation of an enzyme. Endocytosis: membrane pinches inward to make a vesicle, usually receptor mediated to capture proteins, from outside to inside. Secretory vesicles dock and fuse with the plasma membrane at specific. Vesicle can connect and disconnect several times before contents are. Since only part of the contents are emptied in one kiss, this process can be repeated several times before the vesicle is depleted low rate of signalling.
