PSL300H1 Lecture 3: PSL300H1 Endocrine Lecture 3 Summer 2014
Document Summary
6:59 pm: how do hormones signal? o. Common features of signal pathways: existing target proteins. Can be multiple receptors for one ligand or more than one ligand for a receptor o o o (e. g. epinephrine and norepinephrine) o o o. Variable number in target cell (~500 -100, 000) Located in cell membrane, cytoplasm, nucleus: properties of receptors. Binding is reversible: what are the two main types of receptors? o o o o o o. Rapid responses: how hormone/receptor binding to dna alters gene transcription o o o o o o o, hormone response elements = specific dna sequences e. g estrogen response element in dna. Only genes with the response element will be activated/ repressed: plasma membrane receptors. Binding of these hormones can open ion channels or bind on ion channels. Integrin receptor: alters he cytoskeleteon o o o pathways o: g protein-coupled receptors ( gpcrs) Targets: alter enzyme activity (e. g. adenylyl cyclase; phospholipase c(plac)
