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PSL300H1 (220)
Lecture

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Department
Physiology
Course
PSL300H1
Professor
Doug Mac Kay
Semester
Fall

Description
Membrane PotentialSeptember 12 2007Membrane Potentialan enzyme ion pump must work to create a concentration gradient of ion species across the cell membranesemipermeable membrane allows one ion species to diffuse across more than othersodiffusion of that ion species down its concentration gradient creates electrical gradientNaK PumpNaKdependent ATPaseenzyme that moves Na out of cell and K into cellfor each ATP molecule broken down 3 Na ions are pumped out and 2 K pumped inthe pump consumes 13 of energy needs of body enhanced by thyroid hormoneo23 of energy for neurons for the pumpsNaK inequalitypotential difference of 10 mVosmall potential differenceResting Potentialresting membrane is most permeable to K ionK diffuses out of cell down concentration gradient via 2pore family of K channelsK accumulate outside membrane leaving a net negativity inside membraneEquilibrium potentialequilibrium potential potential difference across membrane potential is strong enough to prevent more K outoat equilibrium electrical work to repel outward cation diffusion equals chemical work of diffusion down concentration gradient
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