PSL300H1 Lecture Notes - Lecture 3: Protein Kinase A, Skeletal Muscle, Hydrophile

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11 Dec 2011
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Complex directly alter gene transcript"n= genomic effects: plasma membrane receptors. Receptor-enzyme receptors type: receptor at cell membrane, cytoplasm, or nucleus, hydrophilic (prots, peptides, catecholamines) , hydrophobic (steroid, thyroid hormones) fuse w only interact w receptors on surface plasma membrane thru to cytoplasm; all 3 ways. What characteristics do receptors share: large prots, families can have several receptors that bind to, can be multiple receptors for 1 ligand or >1 same hormone ligand for a receptor (ex. Adrenergic for adrenalin + noradrenalin: variable # in target cell (~500-100,000) , activated & inhibited. Located in cell membrane, cytoplasm, nucleus depending on biology of organism. Cellular receptors are saturable: over certain amt, no more hormone bound inside cell receptor saturated; only have max effect of hormone. Bind to cytoplasmic receptor receptor shape: ex. Mrna leaves nucleus translat"n on ribosomes in cytoplasm certain prots made.

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