PSL301H1 Lecture Notes - Lecture 5: Vasodilation, Factor Vii, Heparin

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11 Jul 2013
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PSL301H1 Full Course Notes
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Acetylsalicylic acid used in low dosages (baby asprin) to prevent heart stroke or blood clotting. Areas with high numbers of capillary are most susceptible. Vasopressin can be administered that is an anti-diuretic hormone and can act on endothelium cells to increase vwf. An essential blood clotting protein (tissue factor), also known as anti-hemophiliac factor (ahf) administered to hemophiliac patients. Factor viii is produced by the liver and is important in activating factor x. Hemophilia a is a x-linked coagulation disorder. Warfarin (coumadin) blocks the action of vitamin k needed in regulated viii in the blood, an essential factor leading to activation of factor x. Platelets are derivatives from megakaryocytes that belong to hematopoietic stem cell lineage; platelets are colorless cells with no nucleus, they are filled with granules and cytokines required for clotting. Megakaryocytes are giant cells with multiple copies of dna in the nucleus.

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