PSL301H1 Lecture 20: Lecture 20- Glomerular Filtration Rate
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PSL301H1 Full Course Notes
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Location: back of abdomen, at the level of the lower ribs. Afferent arteriole glomerulus bowman"s capsule (to be filtered by nephron) Glomerular capillaries: 3 layers: capillary endothelium (innermost, basement membrane, podocyte foot processes (outside, mesangial cells support cells, contract to alter blood flow. Ultrafiltration: ultrafiltration movement of water (starling forces, permselectivity barrier against macromolecule convection (size, charge, Very high blood flow to kidneys (1l/min; 20-25% of cardiac output) Glomerulus the first top of renal blood: filter solutes & water out of glomerular capillary bowman"s space. Blood left in glomerulus: efferent arterioles (out of kidneys) peritubular capillaries renal vein & inferior vena cava. Regulated by contraction/dilation of arterioles (afferent & efferent) Sngfr = single nephron glomerular filtration rate (nl/min) Sngfr vs. kf (membrane permeability: increase in permeability of membrane (increase in ultrafiltration coefficient) increase in filtration rate. Sngfr vs. a (oncotic pressure: increase in oncotic pressure decrease in filtration rate, increase of pressure pulling water into capillary higher resistance against filtration.
