PSL452H1 Lecture Notes - Lecture 1: Cytoskeleton, P2X Purinoreceptor, 5-Ht3 Receptor

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28 Oct 2015
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Structure of the plasma membrane ion channels enable communication from extracellular and intracellular extracellular and intracellular have different ion gradients = creates a signal conduct ion channels : allows ions to move in/out. Equilibrium potential and nernst equation: predicts membrane potential equilibrium potential for individual ions, doesn"t totally apply to a cellular level, permeability issue of cells. Ghk equation: different of membrane potential to the equilibrium potential. Ionic selectivity: e. g. k+, na+, ca2+, cl-, nonselective. Functional properties: voltage-gated channels (e. g. na+ channel, K+ channel, ca2+ channel) ligand-gated channels (e. g. nicotinic acetylcholine receptor, nmda receptor, Gaba receptor: mechanosensitive channels (e. g. swell- activated cl- channels) Molecular structure: based on transmembrane domains, 2 tm channels tetrameric (e. g. inward rectifiers, 4 tm / 2 pore channels (e. g. twik, twok, Task: 4 tm channels pentameric (e. g. nicotinic. Ach channels: 6 tm channels tetrameric (e. g. voltage- gated k+ channels, 24 tm channels (e. g. voltage-gated na+ and ca2+ channels) sodium going into cell = depolarization.

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