PSL452H1 Lecture Notes - Lecture 4: Nifedipine, Second Messenger System, Dihydropyridine

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28 Oct 2015
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Lecture 6: voltage-gated ion channels - molecular basis of ion channel regulation. Pq-type 2. 1: also found in presynaptic termini - supports transmission - purkinjie cells. Forward trafficking of cardiac ion channels (ca1v - myocyte) gap junctions made of connexion connection between 1 myocyte to another is via gap junctions: 2 hemichannels connection them 1 from each cell. Bint: cause localization of calcium and facility calcium to insert into bilayer. Myocytes have a specific structure called t-tubules. Through the microtubule, vesicles packed with l-type calcium channels localizes it to the membrane to be expressed. Modulation of l-type channels by signaling pathways regulation of l-type ca2+ channels by protein kinase a (pka) and protein kinase c (pkc) pathways. Multiple g protein coupled receptors act through camp/pka pathways to regulate l-type channels. Adrenergic receptor stimulation results in a marked increase in ica, which is mediated by a camp/pka pathway. Both 1c and subunits of the channel are substrates for pka in vivo.

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