PSL452H1 Lecture Notes - Lecture 2: Arachidonic Acid, Evolutionary Algorithm, Integral Membrane Protein
Document Summary
Lecture 2: voltage-gated ion channels, classification and diversity of ion channels, molecular. 1952 hodgkin and huxley: measurement of ina and ik, major components of the action potential (nobel prize: first study to record ion flow. 1962 narahashi: tetrodotoxin specific blocker of ina: pharmacological tools to block ion channels blocks sodium voltage gated channels. 1977 neher and sakmann: single channel recording using patch clamp technique (nobel prize 1991) 1998 mackinnon: crystal structure of a k channel (nobel prize 2003) Superfamily (143 members: k+ channels, na+ channels, ca2+ channels, cl- channels. Also families of: ca-activated k+ channels (kca, atp-dependent k+ channels (katp, cyclic nucleotide-gated ion channels (cng, hyperpolarization-activated cyclic nucleotide modulated channels (hcn, transient receptor potential channels (trp) Multiple types of ion channels in a single cell. May fine tune timing and duration of depolarization/hyperpolarization: compartmentalization: we have ion channels on the axons of dendrites, each different compartment of the cell will express a different set of ion channel.
