PSL300H1 Lecture Notes - Lecture 2: Goldman Equation, Threshold Potential, Membrane Potential
Document Summary
K, na and cl with their relatively permeability (remember that k is the major player at rest. = has the greatest permeability whereas na and cl have low permeability: actual membrane potential can be calculation from an expanded equation containing a term for each diffusible ion species. Goldman equation: from the goldman equation, em can be calculated and is about -70mv, puts all concentrations into account. Na+ equilibrium potential: under, certain circumstances, the permeability of na+ can be dominant and much more than the k+ and mp can change drastically. Psl300 cellular neurophysiology: therefore, the cl- ions tend to be more concentrated on the outside in the extracellular space, this is due to anion proteins present on inside and not due to active pump (all electrical for. In normal resting mp, this na+ channel is shut! by a certain amount: this na+ channel is normally closed at -70mv, the activation gate closes the channel.
