PSL300H1 Lecture Notes - Lecture 5: Nephron, Distal Convoluted Tubule, Prostate Cancer

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Male 68 years of age presents at a physician"s office, he has previously been treated for prostate cancer, has a history of marathon running and plays seniors ice hockey. He reports an increase in the number of falling incidents and recently attended the emergency room with a fractured wrist which is not healing. Morning acth- 7 pg/ml (normal 10-65 pg/ml) low. What would you expect to happen to plasma calcium levels in the presence of high. You expect it to be low, so this is an abnormal finding since pth is high and calcium is normal. Individual being treated for prostate cancer with corticosteroids/cortisol inhibits release of crf and acth because plasma cortisol levels are high. Osteoporosis; weakened bones due to chronic high cortisol due to prostate cancer treatment. But osteoporosis is common in active men in 60s; can actually be more serious than in aging women.

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