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Lecture 5

PSL300H1 Lecture Notes - Lecture 5: Ace Inhibitor, Aquaporin, Vasoconstriction


Department
Physiology
Course Code
PSL300H1
Professor
Michelle French
Lecture
5

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Lecture 5- Water & Ion
Balance
Water in the body
Kidney
The Nephron
- Human is 55% water
o Intracellular fluid—2/3 of human’s water
o Extracellular fluid: 1/3
Interstitial fluid (b/w cells) 75%
Plasma 25%
- Water is most important in the PLASMA
o b/c responsible for distributing nutrient & excreting waste from
body
- Water can freely move through all 3 compartments (intercellular,
extracellular)
o ex. Na+
cannot go into the cellsstays in plasma & interstitial
fluid
can lead to water movement across the membranes
(concentration gradient)
Water excretion: urine, feces, sweat & breath
Location:
- posterior of the body, behind the liver
o left kidney is higher, b/c right side has the liver
- Renal
Functions:
- Regulates blood volume
- Excrete waste
- Controls electrolyte concentrations
- Blood pH
- Vitamin D production (remember… PTH)
Cortexoutside layers
Medullainside layers
Calycesfor collecting urine renal pelvis ureter
- The functional unit of the Kidney
Function: take blood, and separate out the nutrients from the waste, and excrete
the waste
- Will not filter certain larger molecules that the body requires
o Ex. Hemoglobin, white blood cells, etc.
o Too large to easily be reabsorbed
o If body needs to get rid of it, can degrade and recycle
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