PSL300H1 Lecture Notes - Lecture 3: Nuclear Pore, Grb2, Estrogen Receptor
Document Summary
Types of receptors: intracellular receptors (bind lipid soluble hormones, cytosolic and nuclear. Either binds to cytoplasmic receptor or goes into the nucleus where it binds to a nucleic receptor. recruited and it is either increased or decreased. Hormone receptor complex (changes conformation to bind to hre) Hormone response element (hre) mrna transcribed mrna leaves cell through nuclear pore to code for proteins. When hre binds, other activators/repressors of transcription are. It takes time for synthesis of protein through this method: plasma membrane receptors, g protein coupled receptors. G protein binds to gtp, gdp kicked off. Atp -> camp camp activates protein kinase - a (pk-a) Many different types fo g proteins: gs, gi, gq etc. Pathway (gs activates adenylyl cyclase) camp formation and breakdown. Signal molecule activates receptor and associated g protein. G protein activates phospholipase c (pl-c), an amplifier enzyme.
