PSL301H1 Lecture Notes - Lecture 5: Mhc Class I, Chymotrypsin, White Blood Cell

• School: UTSG
• Department: Physiology
• Course: PSL301H1
• Professor: Michelle French

Document Summary

Recall: t cell receptors bind to antigens that are bound to mhc. Defending body against intracellular pathogens is the role of the cytotoxic. T lymphocytes, which carry out cell- mediated immunity. Cytotoxic t cells bind to cells that display foreign antigen fragments as part of a major histocompatibility complex (mhc) on their surface. T lymphocytes develop in the thymus gland. Immature precursor cells migrate from the bone marrow to the thymus. During development, cells that don"t react with self form clones and insert t cell receptors into their cell membranes (which are not antibodies like the b cell receptors). So, t cells cannot bind to free-floating antigens as b cells do instead they bind only to. Mhc-antigen complexes on surface of apc (macrophages, tissue cells, etc. ) Tc cells bind to mhc class i, th cells bind mhc class ii. When t cells bind to the antigen presented on the mhc receptors.