PSL301H1 Lecture Notes - Lecture 21: Distal Convoluted Tubule, Proximal Tubule, Efferent Arteriole
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PSL301H1 Full Course Notes
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What transporters are found on the proximal tubule. 1ml/min 80% comes out the efferent arteriole, 19% of the 20% filtered gets reabsorbed. Polarization of transport proteins na/k atpase found on basolateral membrane (facing blood) and sodium/hydrogen exchanger (nhe), sodium cotransporter, sodium channel and organic acid transporter found on luminal membrane: nacl, water, k, bicarbonate, glucose/phosphate/aa cotrasnporters, nhe3. Ncc (na/cl cotransporter) inhibited by diuretic thiazides (more potent than furosemide b/c this segment absorbs less na) Distal convoluted tubule: enac increased number by the action of aldosterone, aquaporin2 increased number by the action of vasopressin. Not really -> lumen is negative: proximal 60%ish, thick ascending loop of henle 20-30, distal 5-10, collecting duct 1-3% Plasma [glucose] until maximum transport is reached at 375mg/min. Yes, until renal threshold of 300mg/100ml of plasma is reached. Co-transported with na+ -> enter ecf using glut transporter.
