PSL301H1 Lecture Notes - Lecture 31: Aromatic Amino Acids, Trypsin Inhibitor, Brush Border
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PSL301H1 Full Course Notes
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Mouth 5% of starch broken down to maltose by salivary amylase. Stomach digestion continues until amylase exposed to low ph (~35% broken down) Small intestine pancreatic amylase is more potent that salivary amylase. Brush border enzymes (on microvilli) breaks down specific carbs. Sglt1 glucose or galactose; activity dependent on na+/k+ atpase. ** these enterocytes do not use glucose as an energy source, keeping glucose levels high inside the cell ** Enterocytes use glutamine and colonocytes use butyric acid. Begins in the stomach pepsin (from pepsinogen), an endopeptidase that cleaves proteins at aromatic amino acids (phenylalanine, tryptophan, tyrosine) Pancreatic enzymes delivered in an inactive form (zymogens) via the sphincter of oddi into the duodenum. Enteropeptidase in brush border converts trypsinogen into trypsin; trypsin activates all of the other enzymes. ** this prevents autodigestion of the pancreas zymogens are packaged in the cytoplasm; trypsin inhibitors are synthesized; trypsin lyses itself (autolysis)
