PSL301H1 Lecture Notes - Lecture 4: Basophil, Interleukin, Mast Cell

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17 May 2016
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PSL301H1 Full Course Notes
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Antibody functions: antibody binds to antigen first. Fc region of antibody-antigen complex to bind to fc receptors on an immune cell. A single fc receptor eliminates need for immune cells to have multiple different receptors that recognize different antigens. Immune cells are activated by any antibody-bound antigen. If immune cell is a phagocyte, fc binding initiates phagocytosis, in which antibodies perform the following. If immune cell is a nk cell or esinophil fc binding. Activates cytotoxic cell responses: release chemicals that destroy antibody-bound antigen, nonspecific response of cytotoxic cells to antibody binding is called antibody-dependent cell-mediated cytotoxicity. Inactivating bacterial toxins: antibodies bind to and neutralize some toxins, when developing vaccines, it trigger antibody production without causing symptoms of disease. Have ige antibodies attached to their surface. When antigens or complement proteins bind to ige, mast cells degranulate, releasing chemicals that mediate inflammatory response. Once antigen is bound, activated b cells differentiate into plasma cells and secrete more antibodies.

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