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Lecture

PSL440Y1 Lecture Notes - Motor Learning, Globus Pallidus, Proprioception


Department
Physiology
Course Code
PSL440Y1
Professor
A

Page:
of 8
INTRODUCTION
The central motor system is arranged as a hierarchy of control levels, with the forebrain at the
top and the spinal cord at the bottom (see Table 14.1).
The highest level concerned with strategy the goal of the movement and the
movement strategy that best achieves that goal
The middle level is concerned with tactics the sequences of muscle contractions,
arranged in space and time, required to smoothly and accurately achieve the strategic
goal
The lowest level is concerned with execution activation of the motor neuron and
interneuron pools that generate the goal-directed movement and make any necessary
adjustments of posture
The proper functioning of each level of the motor control hierarchy relies so heavily on sensory
information that the motor system of the brain might be considered a sensorimotor system.
At the highest level, sensory information generates a mental image of the body and its
relationship to the environment
At the middle level, tactical decisions are based on the memory of sensory information
from past movements
At the lowest level, sensory feedback is used to maintain posture, muscle length, and
tension before and after each voluntary movement.
DESCENDING SPINAL TRACTS
How does the brain communicate with the motor neurons of the spinal cord? Axons from the
brain descend through the spinal cord along two major groups of pathways (see Fig. 14.2):
One is the lateral column of the spinal cord
o The lateral pathways are involved in voluntary movement of the distal
musculature and are under direct cortical control
The other is the ventromedial column
o The ventromedial pathways are involved in the control of posture and
locomotion and are under brain stem control
The Lateral Pathways
The most important component of this pathway is the corticospinal tract (see Fig. 14.3a).
Originating in the neocortex, it is the longest and one of the CNS tracts.
Two-thirds of the axons in the tract originate in areas 4 and 6 and is called the motor
cortex.
The remaining axons derive from the somatosensory areas of the parietal lobe to
regulate the flow of somatosensory information to the brain.
A much smaller component of the lateral pathways is the rubrospinal tract, which orginates in
the red nucleus of the midbrain (see Fig. 14.3b). A major source of input to the red nucleus is
the region of the front cortex that contributes to the corticospinal tract.
It contributes to motor control in many mammalian species
o In humans it appears to be reduced, most of its functions subsumed by the
corticospinal tract.
The Effects of Lateral Pathway Lesions
Experimental lesions in both corticospinal and rubrospinal tracts in monkeys rendered them
unable to make fractionated movements of arms and hands (i.e. could not move their shoulders,
elbows, wrists, and fingers independently).
Voluntary movements were also slower and less accurate
Lesions in the corticospinal tracts alone caused a movement deficit as severe as that observed
after lesions in the lateral columns.
However, many functions gradually reappeared
The only permanent deficit was some weakness of the distal flexors and an inability to
move the fingers independently
Lesion in the rubrospinal tract completely reversed this recovery
o This suggests that the corticorubrospinal pathway was able to partially
compensate for the loss of the corticospinal tract input
The Ventromedial Pathways
It contains four descending tracts that orginate in the brain stem and terminate among the spinal
interneurons controlling proximal and axial muscles:
Vestibulospinal tract
Tectospinal tract
Pontine reticulospinal tract
Medullary reticulospinal tract
The ventromedial pathways use sensory information about balance, body position, and the
visual environment to reflexively maintain balance and body posture
The Vestibulospinal Tracts
The vestibulospinal and tectospinal tracts function to keep the head balanced on the shoulders
as the body moves and to turn the head in response to new sensory stimuli. The
vestibulospinal tracts originate in the vestibular nuclei of the medulla, which relay sensory
information from the vestibular labyrinth (see Fig. 14.4a).
The motion of fluid in the labyrinth (accompanying head movement) activates hair cells
that signal the vestibular nuclei via cranial nerve VIII.
One component of the vestibulospinal tracts projects bilaterally down the spinal cord and
activates cervical spinal circuits that control neck and back muscles (guide head movement).
Another component projects ipsilaterally down to the lumbar spinal cord. It helps us maintain an
upright and balanced posture by facilitating extensor motor neurons of the legs.
The Tectospinal Tract
The tectospinal tract originates in the superior colliculus of the midbrain, which receives direct
input from the retina (see Fig. 14.4b). It also receives projections from visual cortex and afferent
axons with somatosensory and auditory information.
The superior colliculus uses this information to construct a map of the world around us
Stimulation at one site of the map will orient a response that directs the head and eyes
to move to the appropriate point of space
The Pontine and Medullary Reticulospinal Tracts
The reticulospinal tracts arise mainly from the reticular formation of the brain stem which may
be divided into two parts giving rise to two different descending tracts (see Fig. 14.5):
Pontine (medial) reticulospinal tract
Medullary (lateral) reticulopsinal tract
The pontine reticulospinal tract enhances the antigravity reflexes of the spinal cord by
facilitating the extensors of the lower limbs, which helps maintain a standing posture by resisting
the effects of gravity. The activity of ventral horn neurons maintains muscle length and tension.
The medullary reticulospinal tract has the opposite effect. It liberates the antigravity muscles
from reflex control.
Activity in both tracts is controlled by descending signals from the cortex (see Fig. 14.6).
THE PLANNING OF MOVEMENT BY THE CEREBRAL CORTEX
Motor Cortex
It is a region of the frontal lobe consisting of Area 4 (often referred to as primary motor cortex
or M1) and Area 6 (see Fig. 14.7). There is speculation that area 6 might be specialized for
skilled voluntary movement. It was later shown that electrical stimulation of area 6 could evoke
complex movements of either side of the body.
Wilder Penfield found two somatotopically organized motor maps in area 6:
o One in a lateral region called the premotor area (PMA)
innervate proximal motor units
o One in a medial region called the supplementary motor area (SMA)
Innervate distal motor units directly
The Contributions of Posterior Parietal and Prefrontal Cortex
A mental body image seems to be generated by somatosensory, proprioceptive, and visual
inputs to the posterior parietal cortex. Two areas of interest in the posterior parietal cortex are:
Area 5 target of inputs from the primary somatosensory cortical areas 3, 1, and 2
Area 7 target of higher-order visual cortical areas such as MT
Patients with lesions in these areas show bizarre abnormalities of body image and the
perception of spatial relations