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PSY100 - Abnormal Development

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Michael Inzlicht

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Abnormal Development: Thyroid Hormones Role Nov 3, 2009
Cognitive Development
-Piaget; childhood development stages (seonsomotor, concrete operational)
-Brain development; maturing and growing during fetus
-Brain development drives cognitive development
Factors that Regulate Brain Development
-Environmental (drugs, stress, diet)
-Biological (genes, protein, hormones)
Thyroid Hormone
-Thyroxine (T4); iodine, COOH, H2N, four iodine, produced the most
-Triiodothyronine (T3); three iodine, most active hormone
-Thyroid Gland; located in neck near voice box
-Thyroid system; hypothalamus -> TRH ->anterior pituitary -> TSH -> thyroid -> T3 and T4
(<- iodine) [ negative feedback T3 and T4 -> anterior pituitary ]
-Normally, mothers T4 level then fetuss thyroid gland develops and exceeds the mothers
-When fetus’s thyroid gland doesnt develop properly, fetus’s own supply of thyroid is limited
to mothers
Congenital Hypothyroidism
-Pediatric endocrine disorder that affects between 1 in 3000 to 4000 children
-Caused by lack of thyroid hormone prenatally and in neonatal period
-Was once a leading disorder
-Symptoms: prolonged jaundice, lethargy, feeding problems, constipation, cold to touch, good
babies”- sleep through night
-Signs: large fontanels (soft spots on skull), macroglossia (enlarged tongue), hoarse cry,
distended abdomen, umbilical hernia, hypotonia, skin mottling
- “a cretin, cretinism; age 4 years, ht 24 in wt 16 lb (looks abnormal)
-IQ outcome; twins; twin with CH IQ very below normal
-Later the diagnosis, worse the outcome is
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