PSY100 - Abnormal Development

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6 Apr 2011
School
Department
Course
Abnormal Development: Thyroid Hormones Role Nov 3, 2009
Cognitive Development
-Piaget; childhood development stages (seonsomotor, concrete operational)
-Brain development; maturing and growing during fetus
-Brain development drives cognitive development
Factors that Regulate Brain Development
-Environmental (drugs, stress, diet)
-Biological (genes, protein, hormones)
Thyroid Hormone
-Thyroxine (T4); iodine, COOH, H2N, four iodine, produced the most
-Triiodothyronine (T3); three iodine, most active hormone
-Thyroid Gland; located in neck near voice box
-Thyroid system; hypothalamus -> TRH ->anterior pituitary -> TSH -> thyroid -> T3 and T4
(<- iodine) [ negative feedback T3 and T4 -> anterior pituitary ]
-Normally, mothers T4 level then fetuss thyroid gland develops and exceeds the mothers
-When fetus’s thyroid gland doesnt develop properly, fetus’s own supply of thyroid is limited
to mothers
Congenital Hypothyroidism
-Pediatric endocrine disorder that affects between 1 in 3000 to 4000 children
-Caused by lack of thyroid hormone prenatally and in neonatal period
-Was once a leading disorder
-Symptoms: prolonged jaundice, lethargy, feeding problems, constipation, cold to touch, good
babies”- sleep through night
-Signs: large fontanels (soft spots on skull), macroglossia (enlarged tongue), hoarse cry,
distended abdomen, umbilical hernia, hypotonia, skin mottling
- “a cretin, cretinism; age 4 years, ht 24 in wt 16 lb (looks abnormal)
-IQ outcome; twins; twin with CH IQ very below normal
-Later the diagnosis, worse the outcome is
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Document Summary

Piaget; childhood development stages (seonsomotor, concrete operational ) Brain development; maturing and growing during fetus. Thyroxine (t4); iodine, cooh, h2n, four iodine, produced the most. Thyroid gland; located in neck near voice box. Thyroid system; hypothalamus -> trh ->anterior pituitary -> tsh -> thyroid -> t3 and t4 ( anterior pituitary ] Normally, mother"s t4 level then fetus"s thyroid gland develops and exceeds the mother"s. When fetus"s thyroid gland doesn"t develop properly, fetus"s own supply of thyroid is limited to mother"s. Pediatric endocrine disorder that affects between 1 in 3000 to 4000 children. Caused by lack of thyroid hormone prenatally and in neonatal period. Symptoms: prolonged jaundice, lethargy, feeding problems, constipation, cold to touch, good babies - sleep through night. Signs: large fontanels (soft spots on skull), macroglossia (enlarged tongue), hoarse cry, distended abdomen, umbilical hernia, hypotonia, skin mottling.

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