PSY290H1 Lecture Notes - Pharmacology, Neurotransmitter, Reuptake
Document Summary
Na ions --> action potential spike, followed by closing of channels, triggered by k+ Postsynaptic potential --> computation, by transmitter action, activated by the 4 chmical transmitters. Plasticity = result of transmitter release, or more/less psp. Na-k pump: ions pumped in opposite directions. All potentials = result of moving ions across membrane. Loss of + charged k --> soma more negative. When na is only ion that flows, potential goes up to +50mv --> internal soma more positive. When k free to flow, potential goes down to -90mv --> internal more negative. Hotchkin & huskley --> actually came up with formula to explain k and na ion flow for resting & action potential. Resting condition --> k+ flows best, therefore k controls resting potential --> doesn"t quite reach -90mv due to flow of cl-, keeping resting potential at -70mv. There are k+ leak channels --> (which produce) easier flow.