PSY396H1 Lecture Notes - Curare, Tyrosine, Glutamine
Document Summary
Natural ability of enzyme to sepnd time in resting or active state. Receptor can be either resting closed or active where channel is open receptor switches between them. Equilbirum leans to resting inactive or closed state however some receptors in more active state which is rarity, they exist. Bindgn nt shifts eq from inactive to inactive. Resting state and active state between two conformational states equ shifted to resting however as is receptor is active and producing some effect. Add drug agonist eq from rest move to active induce stronger biological effect. Antagonist not shift eq but atagosnit come to play when natural agonist trying to bind to receptor sites. Inverse to resting state or being closed as opposed to active state. Perm to some but large molecules can cross. Capsule selects what chemicals get to the brain. Also low solubility in fat bc need to cross several membranes that are fat. Main component of bbb is glial cells.
