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Lecture 9

PSY396H1 Lecture Notes - Lecture 9: Autoreceptor, Amnesia, Posttraumatic Stress Disorder

Course Code
E.De Rosa

of 3
lecture 9: psy396
June 12,2012
-not responsible for:
- amygdala and fear condtioning
- hypothalamic HPA Axis
-Anti convulsants
Anxiety disorders
- anxiety is suppose to be acute episodes but not chronic
- interfering with your normal functioning
- people who are diagnosed have this interfering
fear: is a natural response to a threat
phobias: are an unrealistic response to something that is non threatening
panic attacks: extremely intense and unpredictable
- comes with behavioral and cognitive symptoms
anxiety: a generalized feeling of fear
- future oriented
Generalized Anxiety Disorder:
- long level anxiety and worrying
- chronic
- anticipating something
Stress related anxiety:
- functions well
- emerges in face of events
Panic Disorder:
- increase surge of activity
- start to feel anxiety because they don't know when the next one will come
Social phobias:
- experienced only when person in social and interpersonal settings
Generalized Anxiety Disorder:
-cormorbiity with depression so have CBT
- anxiety people seems fine outside, inside you feel differently
-ardernergic system is stimulated
- those with social phobias respond to SSRI really well
Drug treatment for anxiety
BNZD: less addictive but suseptible for breathing problems
Serotonergic Anxiolytics:
- if someone is taking BNZD and drinking= dangerous
- BNZD are used for alcholics to get off drinking
- delay of onset: takes a long time
- the BNZD dissolve in mouth and fast onset
- combine both drugs
- a lot of doctors might give beta blockers while in well as waiting
for the sertonergic drugs to take affect
Slide 17:
Partial angonist at 5HT1A
-anxiolytic effects occur quicker than depressive affects?
slide 18
-having beta blocker is one form of anxiolytics treatment
- angonist of autoreceptors
-slide 23
- gaba a seems to have anxiolytics effect
people with GAD have lowe levels of bnzd receptors
- Slide 32:
give flumazenil to be an antagonist for bnzd overdose
slide 36
- compulsion decreases anxiety
- they know that this is not normal behavior
- sometimes life stressor might bring it on
-actions helping to prevent anxiety
- ocd have higher risk of parkingsons
-needs a higher dose
- ocd, anxiolytics take a long time to take affect
-maybe different mechanism than with depression
- patient compliance is high
- low oxygen might indicate that someone may have pd
-too much noreadrenaline and don't turn it down
-bnzd shifts back to typical spectrum
- responds really well to CBT
-combined with pharmaecological treatments
-more responsive like depression
- anti depressive time frame
- more sensitive to ssri, so give them a lower dose
-combine ssri with other drugs like bnzd and therapy
- very specific to what is inducing the anxiety not like panic disorder
-the amount of anticipation of a fearful response
-a fearful event occur with threat
- during 4-6 weeks, re experience the event
-diagnosis of ptsd was very strong after vetnam war
- usually no first line of phar. treatment
- usually start with cbt
-try to give amnestic drugs, to prevent you from encoding the event