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Lecture

PSY396 MAY 13.docx

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Department
Psychology
Course
PSY396H1
Professor
Ljubojevic
Semester
Summer

Description
PSY396 MAY 13, 2013 3/4/5 Lecture format Cell - Know basic componesnt sof the cell Next - Lipid bilayer – fat molecules pair of tails pact densly and two layers of them - Semi permeable membrane – means allows passage of some molecules not allow passage of laeger ones or anions charged particles - Charged particles and larger ones need specific channel built for them - Nucleus hold dna and genetic material to replicate and send infor from one gen to another - Between nuc and membrane is cytoplasm contains is cytosol which is liquid gel and organells that float - Orgnaeeles different organs do specific ducntion Mito - Work as powerplants produce energy to drive various processes - Consume chem. Energy in form of atp - Made in mitochondria and sent to various parts of cell - Er - Complex web of memebranes and vessles - Protein synh - Riosomes – units that make proteins – translate rna to string of aa to proteins Golgi - Golgi - Next step in protein synth - Seres as post office where difernt chemicals are packaged and addressed to different parts of cells - Lysome - Waste processing not used digested basic parts - Vac and ves - Encasing in membrane and store materials - Vacuoles large vesiceles Proteins - Mediators of vast majority of cell functions - Each cell contains same genetic material - Which parts genetic material expressed as protein result in function - Protein long chain of aa - Polypeptide is chain of diff aa - Polypeptide colpases on self and 3d strucuture to become function protein - String of aa in protein by code in gene Dna rna - Genetic material translated to messenger material rna translated to proteins Next - Proteins formed take up vary different roles - Proteins structure role – skeleton of cell or matrix between cells - Proteins serve as enzymes facilator of favorable chemical reactions – rxn not happen on own will occur - Signaling – within and between cells - Recieveers as in receptors or signals themsevels - Transport – channel for different chemicals - Transcription factors what actually results in protein expression of gene determined by neighboring areas called regulatory regions “promoters” of certain genes Group 5 june 10 th - Psychosis and schizophrenia Transmission of info in the nervous system - Brief summary of the lectures - Look into the brain and how different cells communicate - All theses processes aris from simple things - Neurotransmission be broken down 4 steps - How send long disatance - Next ap reaches end of axon and nts released to synapse - What are ex and in psp Intro electrochemical gradiant - Sum of electrical and chemical forces acting on molecule or ions that drive this ion in or out of the cell Chemical - Vessel some sort impermeable membrane - Moving around and - Happens membrane becomes permeable - Simple diffusion through random movement move from higher con to lower con - Apparent movement of ions due to simple diffuisn from high to low is chemical gradient - Quantify the force from left to right is the g = rtln of con left over right - R is is gas constant - T is absolute temperate - Both basically constant - Force higher if large concentration - Till equal both sides Electrical gradient - Charged particles - Left more positive right more negative charged far from organic sustem - Opp attract - Distinct difference in charge around the membrane - Potential look like battery works on differences in potential - Difference in charge between both sides is membrane potential - Same t actual cell membrane - Outside more positive and more negative inside - Membranes are largely impermeable to charged molecules - Make it permeable force drviin charged particles to left and right - G zfv - Z is charge = is positive is 1 - Positive to right until gets to zero – membrane potential Electrochemical gradient - Closer to exsiting - Two compartments - Positive anions a and negative stuck on left - Membrane potential is zero - Open membrane chemical force acting on molecule a driving to right bec no A on right - Each positive ion leaves unmatched negative on left - More positive right and negative left creating membrane potential - Electrol forces acting on a pushing to the left - And chemical as well - Electrical and chemical forces At equilibrium - Left open the membrane two forces will be spent - Flow until reaches stage of equilibrium until no substantial force acting on A - Elchm gradient becomes 0 - Forces balanced out - G chmicla force equal to g electrical force - Zfv = rtln(chmr/chml) - Rearrange to calculate equilibrium potential - Rearrange of both formuals is Nernst equation - Know what it means – what influence eq potential - Charge and concentration and temperature In neurons - Membrane potential is -70mv - Rough outline of the membrane - Extracellular and cytoplasm or inside of cell - Importantion species ion is k cl and proteins themselves the amino acids used to build proteins are negatively charged
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