PSY492H1 Lecture Notes - Lecture 6: Protein Synthesis Inhibitor, Apical Dendrite, Receptor Tyrosine Kinase
Document Summary
Synaptic connections can be modified using a high frequency stimulus and a low frequency stimulus: high frequency stimulation applied results in an ltp, low frequency stimulation applied results in reduction of potential and ltd. A weak high-frequency stimulus (hfs) induces a short-lasting. Ltp (s-ltp) modification and re-arrangement of existing proteins. A strong hfs produces a long-lasting ltp (l-ltp) Pretreatment with anisomycin, a protein synthesis inhibitor prevents the strong stimulus from producing l-ltp, but leaves the early-phase, short-lasting component intact. Implicates that enduring synaptic changes (consolidation) depends on generation of new proteins. High-frequency stimulation initiates local translation and genomic signaling. The stimulation of a postsynaptic neuron activates (a) second messengers that then activated (b) protein kinases. Second messengers or their kinases targets translocate into the nucleus where they phosphorylate creb and transcription is initiated. Soma-to-nucleus signaling then the product comes back to the activated spine. This assumes that chemicals signals are transferred from dendrite to cell body.
