BIOC 300B Lecture Notes - Lecture 9: Calcitonin Gene-Related Peptide, Neural Cell Adhesion Molecule, Intron
13 Feb 2018
School
Department
Course
Professor
Document Summary
Generates protein diversity ex: in thyroid cells > calcitonin in neuronal cells > cgrp (regulates the calcitonin gene) Gene that codes for regulating axon outgrowth. Allowance or inheritance depends on splicing of vase. If vase omitted, promoted axon outgrowth in embryonic phase ex: slowpoke: gradient of 576 isoforms creates tonal range. Encodes ca activated channel in hair cells. Distance from apical to basal end of auditory nerve. We can modify the ability of change to bind calcium thus changes potential across the membrane and frequency. Differentiates b/w embryonic vs. adult because dif. genes are expressed in dif. tissues which implies that alternative splicing is highly regulated. 1 class mediates silencing, the other class enhances gene production. Silencers are bound by hnrnp proteins (found in exon and introns) Binding of proteins to regulate sites in primary transcript. Enhancers increasing use of splicng, enhancing = improving weak splice site.
