BIOC 300B Lecture Notes - Lecture 28: Glycogen Phosphorylase, Blood Sugar, Glycogen

• School: University of Victoria
• Department: Biochemistry
• Course: BIOC 300B
• Professor: Romaniuk Paul

Document Summary

Unlike other sugars, glycogen does not have a reducing end (not opening and closing) > its reducing end is tied up . Most glycogen (lb for lb) is found in the liver while muscle only contains 2%, but overall we have more muscle than liver therefore majority of our glycogen is present in the muscle. The liver is more actively recycling glycogen as it is in change of blood glucose homeostasis (must feed the brain) At the centre of the glycogen cluster is a a protein core called glycogenin > attached to the reducing ends of glycogen (hence no free reducing ends) Branching: vertical = alpha 1,4 linkage side shoots = alpha 1,6 branch. Branching structure is organized into 2 layers white: only alpha 1,4 linkage grey: heavy branching (1,6) Fairly compact granule, not soluble in water. Stored in cells as glycogen granules (dense storage form) glycogen metabolism: regulated release and storage of glucose.