BIOC 300B Lecture Notes - Lecture 30: Acetyl-Coa, Isomerase, Beta Oxidation
5 Apr 2018
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Document Summary
The 3 steps of fatty acid processing lipids are mobilized > degraded and transported. 1: fatty acids are activated (step 2a) and transported into mitochondria (step 2b, fatty acids are sequentially broken down into acetyl coa. Overall product yield for even # c fatty acids: Note: in the last cycle, the c4-keto acyl coa is cleaved into two acetyl coa molecules. In the last step you liberate acetyl coa but also produce acetyl coa. Odd numbered double bonds require an addition isomerase. This process of breaking down unsaturated fatty acids skips the rst oxidation step. Once isomerize there is no input our output of energy. This pathways is easier and generates more atp. Even numbered double bonds require an additional isomerase and reductase. The reductase consolidates the double bonds into a trans-delta-3 enoyl coa. This is a substrate for the same isomerase as the rst on the cis bond (multi purpose isomerase)
