BIOC 300B Lecture Notes - Lecture 33: Citric Acid Cycle, Half-Life, Oxaloacetic Acid

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Lecture 33: amino acid catabolism supplementary information: state the fate of exogenously supplied amino acids that are not used for biosynthesis, discuss dietary protein digestion and degradation. Dietary protein needs to be digested because it contains essential amino acids that humans cannot make (his, ile, leu, met, phe, thr, trp, val) Enzymes from the pancreas aid in digestion while in the intestine. Acidic ph of the stomach will denature proteins and make them accessible to pepsin in the small intestine. Pepsin hydrolyzes the peptide bonds, and optimally functions at ph 2. 0. Plasma membrane protease works from the amino end. Once broken down into amino acids and oligopeptides, they are moved into intestinal cells via speci c transporters from the lumen. Inside the intestinal cell, peptidases convert everything into amino acids releases them into the blood. Ubiquitin is covalently attached via it"s c-terminal glycine to the lysine of target proteins to signal them for degradation.

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